Linked Life Data

19765576

Source:http://linkedlifedata.com/resource/pubmed/id/19765576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2009-10-19
pubmed:abstractText
NR2A-containing N-methyl-D-aspartate (NMDA) receptors have important roles in influencing the long-term potentiation and spatial memory. Here using Morris water maze, we found that inhibition of NR2A-containing NMDA receptors by [(R)-[(S)-1-(4-bromophenyl)-ethylamino]-(2, 3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) hindered the formation of spatial memory. An increasing number of reports suggest that adult hippocampal neurogenesis is involved in hippocampal-mediated learning. To explore the possible mechanisms understanding the reduced spatial memory by NVP-AAM077, we investigated the effects of NVP-AAM077 on neurogenesis. We found that NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice. In null mutant mice lacking neuronal nitric oxide synthase (nNOS) gene (nNOS(-/-)), the effects of NVP-AAM077 on neurogenesis disappeared. In addition, NVP-AAM077 increased nNOS enzymatic activity. Our findings suggest that NVP-AAM077 reduced spatial learning through down-regulating neurogenesis in the adult hippocampus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1879-0712
pubmed:author
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
622
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-44
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis.
pubmed:affiliation
Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't