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rdf:type |
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lifeskim:mentions |
umls-concept:C0020099,
umls-concept:C0020792,
umls-concept:C0033684,
umls-concept:C0086427,
umls-concept:C0205314,
umls-concept:C0332307,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C1273518,
umls-concept:C1413560,
umls-concept:C1510411,
umls-concept:C1514562
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pubmed:dateCreated |
2009-9-30
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pubmed:abstractText |
Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia (ATL), whereas its relative HTLV-2 is not associated with any malignancies including ATL. HTLV-1 Tax1 transformed a T-cell line from interleukin (IL)-2-dependent growth to IL-2-independent growth, with an activity that was much more potent in comparison to HTLV-2 Tax2. This distinction was mediated by at least two Tax1 specific functions, an interaction with host cellular factors through the PDZ domain binding motif (PBM) and the activation of NF-kappa B2 (NF-kappa B2)/p100.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-11145887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-11726516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-11861831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-12670929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-1351105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-1386673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-1427072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-14972558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-15661157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-15743528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-15882466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-15911757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16042787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16155602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16155603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16155604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16285885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16532031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16970925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-16973592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17042961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-1710610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17119127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17127397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17384582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17703191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-17715223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-18239685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-18377428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-18573107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-18702816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-18922151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-19187529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-3026643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-3030566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-8437212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-8764028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19761585-9882331
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-4690
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19761585-Amino Acid Motifs,
pubmed-meshheading:19761585-Animals,
pubmed-meshheading:19761585-Cell Line,
pubmed-meshheading:19761585-Cell Transformation, Viral,
pubmed-meshheading:19761585-Conserved Sequence,
pubmed-meshheading:19761585-Gene Products, tax,
pubmed-meshheading:19761585-Human T-lymphotropic virus 1,
pubmed-meshheading:19761585-Human T-lymphotropic virus 2,
pubmed-meshheading:19761585-Humans,
pubmed-meshheading:19761585-Leukemia, T-Cell,
pubmed-meshheading:19761585-Mice,
pubmed-meshheading:19761585-NF-kappa B,
pubmed-meshheading:19761585-Primate T-lymphotropic virus 3,
pubmed-meshheading:19761585-Recombinant Proteins,
pubmed-meshheading:19761585-Simian T-lymphotropic virus 1,
pubmed-meshheading:19761585-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.
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pubmed:affiliation |
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata 951-8510, Japan. shoji-t@med.niigata-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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