Linked Life Data

1975496

Source:http://linkedlifedata.com/resource/pubmed/id/1975496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-10-5
pubmed:abstractText
Mequitazine is a potent, non-sedative, long-acting H1-specific antihistamine proven to be a better therapeutic drug than other conventional antihistamines. It is also reported by many authors that the drug produces less sedative or other depressive actions on the central nervous system than other antihistamines. In order to evaluate the advantage of this drug in Asian people, an assessment of side effects of mequitazine, in comparison with chlorpheniramine, on the central nervous system was done in 20 healthy Thai volunteers, 10 males and 10 females 23-39 years of age, using a double blind crossover placebo controlled trial. Various subjective tests: alertness scale rating, visual analogue scale rating as well as objective tests: card sorting, glassbead picking and estimation of reaction time, were performed. There were no significant differences in side effects on the central nervous system between mequitazine and the placebo, whereas chlorpheniramine did produce side effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0125-877X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A study on CNS-side effects of mequitazine, an H1-specific antihistamine in healthy Thai volunteers.
pubmed:affiliation
Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial