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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-8-30
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pubmed:abstractText |
We studied 83 lung cancer patients and 129 controls for the EcoRI polymorphism of the L-myc gene. No association was found between the L-myc RFLP and increased risk of metastasis, either to lymph nodes or metastasis to other organs. There was no difference in survival time between the three different genotypes. The S-allele of the L-myc RFLP has been correlated to increased metastasis in lung cancer. We found no tendency towards a higher frequency of this allele in the cohort of patients with positive family history compared to the patients with no known first degree relatives with cancer. A higher frequency of the S-allele in the adenocarcinomas compared to other histological groups was found, although this difference was not statistically significant. No difference in the gene frequency of the L-myc RFLP was found between the lung cancer patients and the normal controls. These results are in contrast with a previous report. Possible explanations for the discrepancies are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2419762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2564378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2827002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2838780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2846154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2850489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2895475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-2900827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-3011049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-3034500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-3054516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-3541204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1973618-7157307
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
809-12
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1973618-Adenocarcinoma,
pubmed-meshheading:1973618-Adult,
pubmed-meshheading:1973618-Aged,
pubmed-meshheading:1973618-Aged, 80 and over,
pubmed-meshheading:1973618-Alleles,
pubmed-meshheading:1973618-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:1973618-Carcinoma, Small Cell,
pubmed-meshheading:1973618-Carcinoma, Squamous Cell,
pubmed-meshheading:1973618-Female,
pubmed-meshheading:1973618-Genotype,
pubmed-meshheading:1973618-Humans,
pubmed-meshheading:1973618-Lung Neoplasms,
pubmed-meshheading:1973618-Male,
pubmed-meshheading:1973618-Middle Aged,
pubmed-meshheading:1973618-Neoplasm Metastasis,
pubmed-meshheading:1973618-Oncogenes,
pubmed-meshheading:1973618-Polymorphism, Restriction Fragment Length
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pubmed:year |
1990
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pubmed:articleTitle |
Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients.
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pubmed:affiliation |
Department of Genetics, Norwegian Radium Hospital, Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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