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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-11-9
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pubmed:abstractText |
We describe 2 patients who developed anti-aquaporin-4 antibody-positive neuromyelitis optica (NMO) following the development of anti-acetylcholine receptor antibody-positive myasthenia gravis (MG). A literature review of 13 similar cases in addition to the present 2 cases of NMO with MG showed predominance among Asian women and frequent development of NMO following thymectomy for MG. Moreover, in one of our patients, serial assays of anti-aquaporin-4 antibody and anti-acetylcholine receptor antibody were performed. Accumulating evidence for the coexistence of NMO and MG suggests that a common immunopathogenesis of NMO and MG may exist, and the association of NMO with MG may be more frequent than hitherto believed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1878-5883
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-7
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pubmed:meshHeading |
pubmed-meshheading:19729173-Aquaporin 4,
pubmed-meshheading:19729173-Asian Continental Ancestry Group,
pubmed-meshheading:19729173-Autoantibodies,
pubmed-meshheading:19729173-Autoimmunity,
pubmed-meshheading:19729173-Biological Markers,
pubmed-meshheading:19729173-Blindness,
pubmed-meshheading:19729173-Central Nervous System,
pubmed-meshheading:19729173-Continental Population Groups,
pubmed-meshheading:19729173-Disease Progression,
pubmed-meshheading:19729173-Female,
pubmed-meshheading:19729173-Humans,
pubmed-meshheading:19729173-Middle Aged,
pubmed-meshheading:19729173-Myasthenia Gravis,
pubmed-meshheading:19729173-Neuromuscular Junction,
pubmed-meshheading:19729173-Neuromyelitis Optica,
pubmed-meshheading:19729173-Optic Nerve,
pubmed-meshheading:19729173-Peripheral Nervous System,
pubmed-meshheading:19729173-Quadriplegia,
pubmed-meshheading:19729173-Receptors, Cholinergic,
pubmed-meshheading:19729173-Spinal Cord,
pubmed-meshheading:19729173-Thymectomy
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pubmed:year |
2009
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pubmed:articleTitle |
Association of anti-aquaporin-4 antibody-positive neuromyelitis optica with myasthenia gravis.
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pubmed:affiliation |
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. a-uzimp1204@graduate.chiba-u.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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