Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8698
|
| pubmed:dateCreated |
1990-7-9
|
| pubmed:abstractText |
A radioimmunoassay was used to detect antibodies to hepatitis C virus (anti-HCV) in 154 patients with haemophilia. Prevalence of anti-HCV was associated with exposure to clotting factor concentrates. 76 of 129 (59%) who had received factor VIII or IX had anti-HCV: 42 of 55 (76%) who required over 10,000 units of concentrate annually had anti-HCV, compared with 34 of 74 (46%) who required less, and 0 of 25 patients who had never received concentrates. Anti-HCV were significantly more common in patients seropositive for antibodies against human immunodeficiency virus (anti-HIV) or with markers of previous hepatitis B infection than in those without anti-HIV or hepatitis B markers (88% vs 39% and 75% vs 46%, respectively). 5 of 23 (22%) haemophiliacs treated only with heated concentrates had anti-HCV compared with 71 of 106 (67%) patients who received unmodified products. 35 patients with chronic liver disease underwent liver biopsy: histological examination showed features associated with post-transfusion hepatitis in 24, all of whom were anti-HCV-positive; of the other 11 patients with no histological features of non-A, non-B hepatitis, 5 were anti-HCV-positive. HCV appears to be the major predisposing factor for most non-A, non-B hepatitis and chronic liver disease in haemophilia.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
335
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1117-9
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:1971863-Adolescent,
pubmed-meshheading:1971863-Adult,
pubmed-meshheading:1971863-Aged,
pubmed-meshheading:1971863-Aged, 80 and over,
pubmed-meshheading:1971863-Alanine Transaminase,
pubmed-meshheading:1971863-Biopsy,
pubmed-meshheading:1971863-Chronic Disease,
pubmed-meshheading:1971863-Evaluation Studies as Topic,
pubmed-meshheading:1971863-Factor IX,
pubmed-meshheading:1971863-Factor XIII,
pubmed-meshheading:1971863-Hemophilia A,
pubmed-meshheading:1971863-Hemophilia B,
pubmed-meshheading:1971863-Hepatitis Antibodies,
pubmed-meshheading:1971863-Hepatitis C,
pubmed-meshheading:1971863-Hepatitis Viruses,
pubmed-meshheading:1971863-Humans,
pubmed-meshheading:1971863-Liver,
pubmed-meshheading:1971863-Liver Diseases,
pubmed-meshheading:1971863-Middle Aged,
pubmed-meshheading:1971863-von Willebrand Diseases
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Hepatitis C antibody and chronic liver disease in haemophilia.
|
| pubmed:affiliation |
Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.
|
| pubmed:publicationType |
Journal Article
|