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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-9-21
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pubmed:abstractText |
There is increasing evidence that the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) plays an important role in controlling cell differentiation, and that PPARgamma ligands can modify inflammatory and fibrotic responses. The aim of the present study was to examine the role of PPARgamma in a mouse model of skin scleroderma, in which mice bearing a fibroblast-specific deletion of PPARgamma were used.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2822-9
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pubmed:meshHeading |
pubmed-meshheading:19714649-Actins,
pubmed-meshheading:19714649-Animals,
pubmed-meshheading:19714649-Bleomycin,
pubmed-meshheading:19714649-Cells, Cultured,
pubmed-meshheading:19714649-Disease Models, Animal,
pubmed-meshheading:19714649-Fibroblasts,
pubmed-meshheading:19714649-Fibrosis,
pubmed-meshheading:19714649-Gene Deletion,
pubmed-meshheading:19714649-Genetic Predisposition to Disease,
pubmed-meshheading:19714649-Mice,
pubmed-meshheading:19714649-Mice, Knockout,
pubmed-meshheading:19714649-PPAR gamma,
pubmed-meshheading:19714649-Scleroderma, Systemic,
pubmed-meshheading:19714649-Signal Transduction,
pubmed-meshheading:19714649-Skin,
pubmed-meshheading:19714649-Smad3 Protein,
pubmed-meshheading:19714649-Transforming Growth Factor beta1
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.
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pubmed:affiliation |
University of Western Ontario, London, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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