Linked Life Data

1971179

Source:http://linkedlifedata.com/resource/pubmed/id/1971179

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-6-26
pubmed:abstractText
In the present study, we employed a dual-immunofluorescent labeling procedure to determine if the biosynthetic enzymes tyrosine hydroxylase (TH) and choline acetyltransferase (ChAT) are co-localized within neurons in the dorsal medulla of rat. Within this region TH-labeled neurons are distributed within the nuclei of the solitary tracts and medial aspect of the dorsal motor nucleus of the vagus. The absence of dopamine-beta-hydroxylase immunoreactivity within TH-labeled cells in the medial portion of the dorsal motor nucleus of the vagus suggests that these neurons are dopaminergic. Cholinergic perikarya also are present in the dorsal medulla and are distributed throughout the dorsal motor nucleus of the vagus and hypoglossal nucleus. Of these ChAT-positive perikarya, a small percentage limited to the medial aspect of the dorsal motor nucleus of the vagus (i.e., corresponding to the location of dopamine neurons) also contain TH. The existence of TH within ChAT-positive neurons in the dorsal motor nucleus of the vagus provides an anatomical substrate with which to suggest that catecholaminergic and cholinergic fibers contribute to the vagus nerve and may serve to explain some of the cardiac and gastric effects resulting from systemic administration of catecholamine agents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0891-0618
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Co-localization of choline acetyltransferase and tyrosine hydroxylase within neurons of the dorsal motor nucleus of the vagus.
pubmed:affiliation
Department of Neurosciences, University of California, San Diego, La Jolla 92093.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.