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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1990-6-20
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pubmed:abstractText |
Of the 645 Japanese subjects studied, we have identified 10 individuals heterozygous for a chromosome with the triplicated alpha-globin loci. The frequency of the triple alpha-loci was 0.008 in this population, while that of the single alpha-locus, i.e., alpha-thalassemia 2 gene, might be lower than 0.0008. Analysis of haplotypes using particular RsaI site polymorphism in the alpha-globin gene complex strongly suggests that the triple alpha loci may have had multiple origins in this population.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0340-6717
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
568-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1970975-Gene Conversion,
pubmed-meshheading:1970975-Globins,
pubmed-meshheading:1970975-Haplotypes,
pubmed-meshheading:1970975-Heterozygote,
pubmed-meshheading:1970975-Humans,
pubmed-meshheading:1970975-Japan,
pubmed-meshheading:1970975-Multigene Family,
pubmed-meshheading:1970975-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1970975-Restriction Mapping,
pubmed-meshheading:1970975-Sequence Homology, Nucleic Acid
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pubmed:year |
1990
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pubmed:articleTitle |
Genetic polymorphisms of gene conversion within the duplicated human alpha-globin loci.
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pubmed:affiliation |
Department of Human Genetics, National Institute of Genetics, Mishima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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