Source:http://linkedlifedata.com/resource/pubmed/id/19709660
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2010-2-1
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pubmed:abstractText |
Recent studies have revealed that sequence variation on chromosome 9p21 is a major genetic determinant for coronary heart disease and stroke, however, the underlying mechanism remains unknown. This genomic region contains the gene encoding cyclin-dependent kinase 2A, a regulator of proliferation and differentiation of endothelial progenitor cell (EPC) which has been implicated in vascular repair and protection against cardiovascular disease. We investigated whether carriers and non-carriers of the chromosome 9p21 variation differed in their number and function of EPCs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-1484
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
451-5
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pubmed:meshHeading |
pubmed-meshheading:19709660-Adult,
pubmed-meshheading:19709660-Aged,
pubmed-meshheading:19709660-Cardiovascular Diseases,
pubmed-meshheading:19709660-Cell Proliferation,
pubmed-meshheading:19709660-Chromosomes, Human, Pair 9,
pubmed-meshheading:19709660-Cohort Studies,
pubmed-meshheading:19709660-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:19709660-Endothelial Cells,
pubmed-meshheading:19709660-Female,
pubmed-meshheading:19709660-Gene Expression Regulation,
pubmed-meshheading:19709660-Genotype,
pubmed-meshheading:19709660-Humans,
pubmed-meshheading:19709660-Male,
pubmed-meshheading:19709660-Middle Aged,
pubmed-meshheading:19709660-Polymorphism, Single Nucleotide,
pubmed-meshheading:19709660-Risk,
pubmed-meshheading:19709660-Stem Cells
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pubmed:year |
2010
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pubmed:articleTitle |
Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort.
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pubmed:affiliation |
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. s.ye@qmul.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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