Linked Life Data

19707959

Source:http://linkedlifedata.com/resource/pubmed/id/19707959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 2
pubmed:dateCreated
2009-12-9
pubmed:abstractText
Methylphenidate is a piperidine derivative and is the drug most often used to treat attention deficit/hyperactivity disorder of children and young adults. Our aim is to investigate dose-dependent dopamine-2 receptor and glial fibrillary acidic protein expression and ultrastructural changes of the rat brain, to demonstrate possible toxicity of the long-term and high dose use of the methylphenidate. In this study, 27 female prepubertal Wistar albino rats, divided into three different dose groups (5, 10 and 20 mg/kg) were treated orally with methylphenidate dissolved in saline solution for 5 days per week during 3 months. At the end of the third month, tissues were removed and sections were collected for immunohistochemical and ultrastructural studies. We believe that methylphenidate causes dose-related activation of the dopaminergic system in several brain regions especially in ventral tegmental area and also causing neuronal degeneration and capillary wall structural changes such as basal membrane thickness and augmentation of the pinostatic vesicle in the endothelial cells. Also, increased dose of Ritalin is inducing astrocytes hypertrophy especially astrogliosis in pia-glial membrane and this is the result of the degenerative changes in prefrontal cortex region due to high dose methylphenidate administration. The dose-related accumulation of the astrocytes in capillary wall might well be a consequence of the need for nutrition of the neuronal tissue, due to transport mechanism deficiency related to neuronal and vascular degeneration. Thus, we believe that the therapeutic dose of methylphenidate must be kept in minimum level to prevent ultrastructural changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1814-1412
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-43
pubmed:meshHeading
pubmed-meshheading:19707959-Administration, Oral, pubmed-meshheading:19707959-Age Factors, pubmed-meshheading:19707959-Animals, pubmed-meshheading:19707959-Astrocytes, pubmed-meshheading:19707959-Capillaries, pubmed-meshheading:19707959-Central Nervous System Stimulants, pubmed-meshheading:19707959-Cerebellum, pubmed-meshheading:19707959-Cerebrum, pubmed-meshheading:19707959-Dopamine, pubmed-meshheading:19707959-Dose-Response Relationship, Drug, pubmed-meshheading:19707959-Endothelium, Vascular, pubmed-meshheading:19707959-Female, pubmed-meshheading:19707959-Glial Fibrillary Acidic Protein, pubmed-meshheading:19707959-Immunoenzyme Techniques, pubmed-meshheading:19707959-Methylphenidate, pubmed-meshheading:19707959-Nerve Degeneration, pubmed-meshheading:19707959-Pinocytosis, pubmed-meshheading:19707959-Prefrontal Cortex, pubmed-meshheading:19707959-Rats, pubmed-meshheading:19707959-Rats, Wistar, pubmed-meshheading:19707959-Receptors, Dopamine D2, pubmed-meshheading:19707959-Ventral Tegmental Area
pubmed:year
2009
pubmed:articleTitle
Dose-related immunohistochemical and ultrastructural changes after oral methylphenidate administration in cerebrum and cerebellum of the rat.
pubmed:affiliation
Department of Anatomy, Faculty of Medicine, University of Gazi, Ankara, Turkey. meltemb@gazi.edu.tr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't