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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-9
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pubmed:abstractText |
Helicobacter pylori infection results in a diversity of pathologies, from asymptomatic gastritis to adenocarcinoma. The reason for these diverse outcomes is multifactorial and includes host factors that regulate severity of Helicobacter-induced gastritis. Protease-activated receptors (PAR) are environmental sensors that can detect tissue damage and pathogens. Whereas PAR-2 has proinflammatory activity and PAR-1 can protect the gastric mucosa against chemical damage, neither has previously been examined for their potential roles in regulating Helicobacter pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
573-82
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pubmed:meshHeading |
pubmed-meshheading:19706295-Animals,
pubmed-meshheading:19706295-Cells, Cultured,
pubmed-meshheading:19706295-Chemokine CXCL2,
pubmed-meshheading:19706295-Disease Models, Animal,
pubmed-meshheading:19706295-Down-Regulation,
pubmed-meshheading:19706295-Epithelium,
pubmed-meshheading:19706295-Gastric Mucosa,
pubmed-meshheading:19706295-Gastritis,
pubmed-meshheading:19706295-Helicobacter Infections,
pubmed-meshheading:19706295-Helicobacter pylori,
pubmed-meshheading:19706295-Immunity, Humoral,
pubmed-meshheading:19706295-Inflammation,
pubmed-meshheading:19706295-Mice,
pubmed-meshheading:19706295-Mice, Inbred C57BL,
pubmed-meshheading:19706295-Mice, Knockout,
pubmed-meshheading:19706295-Receptor, PAR-1,
pubmed-meshheading:19706295-Receptor, PAR-2
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pubmed:year |
2010
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pubmed:articleTitle |
Protease-activated receptor-1 down-regulates the murine inflammatory and humoral response to Helicobacter pylori.
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pubmed:affiliation |
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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