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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-8-25
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pubmed:abstractText |
Human beta-defensins (HBDs) are cationic, antimicrobial peptides produced by epithelial cells and involved in various aspects of the innate and acquired immune responses. They are expressed by oral tissues as constitutive and inducible genes. Recently, single nucleotide polymorphisms (SNPs) of beta-defensins have been correlated with increased susceptibility to certain diseases. Studies have reported altered expression of beta-defensins in cancers suggesting their involvement in carcinogenesis. The purpose of this study was to evaluate the regulation of HBD-1 (also published as DEFB1), HBD-2 (DEFB4) and HBD-3 (DEFB103A) (http://www.genenames.org/index.html) and HBD-1 SNPs in oral squamous cell carcinoma cell lines (OSCC) and healthy gingival keratinocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/DEFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DEFB4A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Defensins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-defensin 3, human
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1399-302X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-60
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pubmed:dateRevised |
2010-9-17
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pubmed:meshHeading |
pubmed-meshheading:19702947-5' Untranslated Regions,
pubmed-meshheading:19702947-Antimicrobial Cationic Peptides,
pubmed-meshheading:19702947-Carcinoma, Squamous Cell,
pubmed-meshheading:19702947-Cell Line, Tumor,
pubmed-meshheading:19702947-DNA, Neoplasm,
pubmed-meshheading:19702947-Exons,
pubmed-meshheading:19702947-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19702947-Gene Frequency,
pubmed-meshheading:19702947-Genotype,
pubmed-meshheading:19702947-Gingiva,
pubmed-meshheading:19702947-Haplotypes,
pubmed-meshheading:19702947-Humans,
pubmed-meshheading:19702947-Interferon-gamma,
pubmed-meshheading:19702947-Interleukin-1beta,
pubmed-meshheading:19702947-Introns,
pubmed-meshheading:19702947-Keratinocytes,
pubmed-meshheading:19702947-Linkage Disequilibrium,
pubmed-meshheading:19702947-Loss of Heterozygosity,
pubmed-meshheading:19702947-Mouth Neoplasms,
pubmed-meshheading:19702947-Polymorphism, Single Nucleotide,
pubmed-meshheading:19702947-RNA, Messenger,
pubmed-meshheading:19702947-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19702947-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19702947-beta-Defensins
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pubmed:year |
2009
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pubmed:articleTitle |
Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma.
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pubmed:affiliation |
Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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