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19700325
Source:
http://linkedlifedata.com/resource/pubmed/id/19700325
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52
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0001688
,
umls-concept:C0002772
,
umls-concept:C0205177
,
umls-concept:C0521346
,
umls-concept:C0879626
,
umls-concept:C1415813
,
umls-concept:C1554184
,
umls-concept:C1704419
pubmed:issue
19
pubmed:dateCreated
2009-9-14
pubmed:abstractText
Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid
,
http://linkedlifedata.com/resource/pubmed/chemical/Cisapride
,
http://linkedlifedata.com/resource/pubmed/chemical/Metoclopramide
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT4
,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT4 Receptor Agonists
,
http://linkedlifedata.com/resource/pubmed/chemical/Tramadol
,
http://linkedlifedata.com/resource/pubmed/chemical/norcisapride
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-3405
pubmed:author
pubmed-author:BarberichTimothy JTJ
,
pubmed-author:HewittMichael CMC
,
pubmed-author:ShaoLimingL
,
pubmed-author:WangFengjiangF
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5679-83
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19700325-Analgesics, Opioid
,
pubmed-meshheading:19700325-Cisapride
,
pubmed-meshheading:19700325-Gastrointestinal Transit
,
pubmed-meshheading:19700325-Humans
,
pubmed-meshheading:19700325-Metoclopramide
,
pubmed-meshheading:19700325-Receptors, Opioid, mu
,
pubmed-meshheading:19700325-Receptors, Serotonin, 5-HT4
,
pubmed-meshheading:19700325-Respiratory System
,
pubmed-meshheading:19700325-Serotonin 5-HT4 Receptor Agonists
,
pubmed-meshheading:19700325-Stereoisomerism
,
pubmed-meshheading:19700325-Tramadol
pubmed:year
2009
pubmed:articleTitle
mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I).
pubmed:affiliation
Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.com
pubmed:publicationType
Journal Article