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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
1990-5-17
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pubmed:abstractText |
IL-4 induces Thy-1 expression and IgE secretion by LPS--and T cell-stimulated murine B cells in vitro. IFN-gamma inhibits both of these IL-4-mediated effects. IL-4 and IFN-gamma are often exclusively produced by different CD4+ T cell subsets. Injection of mice with a polyclonal goat anti-mouse IgD antibody (GaM delta) stimulates large increases in the serum concentration of IgE through the production of IL-4. Neutralization of endogenous IFN-gamma production in GaM delta-injected mice leads to further increases in serum IgE levels. We show that IL-4 and IFN-gamma, produced after GaM delta injection, respectively, stimulate and inhibit the number of splenic B cells expressing Thy-1 in vivo. Increased numbers of Thy-1-expressing B cells are observed concomitantly with the onset of enhanced IgE secretion. These Thy-1-expressing B cells are highly and selectively enriched for IgE-secreting cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
144
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2940-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1969877-Animals,
pubmed-meshheading:1969877-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1969877-Antigens, Surface,
pubmed-meshheading:1969877-Antigens, Thy-1,
pubmed-meshheading:1969877-B-Lymphocytes,
pubmed-meshheading:1969877-Flow Cytometry,
pubmed-meshheading:1969877-Immunoglobulin E,
pubmed-meshheading:1969877-Immunoglobulin Isotypes,
pubmed-meshheading:1969877-Interferon-gamma,
pubmed-meshheading:1969877-Interleukin-4,
pubmed-meshheading:1969877-Mice,
pubmed-meshheading:1969877-Mice, Inbred Strains,
pubmed-meshheading:1969877-Time Factors
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Murine B cells expressing Thy-1 after in vivo immunization selectively secrete IgE.
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pubmed:affiliation |
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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