Linked Life Data

19697507

Source:http://linkedlifedata.com/resource/pubmed/id/19697507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-24
pubmed:abstractText
Acrylic bone cement is self-curing cement comprising of liquid and powder component of methyl methacrylate (MMA). It has been used extensively in orthopedics; however, adverse effects were associated with its use. Hence we investigated in this paper the possibility of new cement utilizing methacrylates with lower toxicity than MMA. LD50s of candidate monomers were determined with administration to the medullary cavity of the rat's femur. 2-Ethylhexyl methacrylate (EHMA) and trimethylolpropane trimethacrylate (TMP) demonstrated greater LD50 values of 187 mg/kg and 380 mg/kg, respectively, than MMA (108 mg/kg); they were selected as the liquid components of the new cement. The copolymer of EHMA and cyclohexyl methacrylate was then selected as the powder component. With this combination, we developed the new cement (EHMA cement).Temperature rise during polymerization of EHMA cement was 9 degrees C-13 degrees C, which was significantly lower than that of conventional cement. The compression strength of the polymerized EHMA cement was 57 MPa without TMP, and 67 MPa with TMP (15 wt%). Thus we concluded that new EHMA cement was slightly inferior in the compression strength than the conventional cement. However, it was characterized by the low toxicity of utilized monomers and the low temperature rise during polymerization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1342-8810
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-96
pubmed:dateRevised
2010-4-12
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Development of new bone cement utilizing low toxicity monomers.
pubmed:affiliation
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
pubmed:publicationType
Journal Article