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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-8-27
pubmed:abstractText
There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer. New bidirectional chemotherapy (neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)) was developed. The aim of the present study was to assess the safety and efficacy of NIPS and to show the selection for cytoreductive surgery on PC from gastric cancer. Seventy-nine patients with PC from gastric cancer were treated with NIPS. A peritoneal port system was introduced into the abdominal cavity. The peritoneal wash cytological examination through a port was done before and after NIPS. The patients were treated with oral TS-1 twice a daily for 21 days, followed by a 1-week rest. On day 1, 8, and 15 from the start of oral TS-1 administration, 30 mg/m(2) of Docetaxel and 30 mg/m(2) of cisplatinum with 500 ml of saline were introduced into the peritoneal cavity through the port. A median course of oral TS-1 was 2.1 course and a median time of IP chemoterapy was 5.8. Peritoneal free cancer cells (PFCCs) had been detected in 65 (82.2%) patients before NIPS, and the positive cytology changed to be negative in 41 (63.0%) patients after NIPS. After NIPS, 41 patients underwent laparotomy, and complete cytoreduction was done in 32 (78%) patients. Complete cytoreduction was done in 27 (51.9%) of 52 patients with negative cytology but in only 4 (14.8%) of 27 patients with positive cytology (P < 0.001). Patients with negative cytology after NIPS survived significantly longer than those with positive cytology. The adverse effects after NIPS were mild and there was no treatment-related deaths. The grade 3/4 hematological adverse effects were found in 2 (2.6%) patients. Grade 3 renal toxicity and port site infection was found in three patients, respectively. NIPS using a port system is a safe and effective treatment for PC. Peritoneal wash cytology through a port system is a good indicator to select the patients to perform cytoreductive surgery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1096-9098
pubmed:author
pubmed:copyrightInfo
(c) 2009 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-6
pubmed:meshHeading
pubmed-meshheading:19697437-Adult, pubmed-meshheading:19697437-Aged, pubmed-meshheading:19697437-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:19697437-Chemotherapy, Cancer, Regional Perfusion, pubmed-meshheading:19697437-Cisplatin, pubmed-meshheading:19697437-Combined Modality Therapy, pubmed-meshheading:19697437-Female, pubmed-meshheading:19697437-Humans, pubmed-meshheading:19697437-Male, pubmed-meshheading:19697437-Middle Aged, pubmed-meshheading:19697437-Neoplasm Recurrence, Local, pubmed-meshheading:19697437-Neoplasm Staging, pubmed-meshheading:19697437-Patient Selection, pubmed-meshheading:19697437-Peritoneal Neoplasms, pubmed-meshheading:19697437-Prognosis, pubmed-meshheading:19697437-Stomach Neoplasms, pubmed-meshheading:19697437-Survival Rate, pubmed-meshheading:19697437-Taxoids
pubmed:year
2009
pubmed:articleTitle
Safety and efficacy of bidirectional chemotherapy for treatment of patients with peritoneal dissemination from gastric cancer: Selection for cytoreductive surgery.
pubmed:affiliation
NPO Organization to Support Peritoneal Dissemination Treatment, Kishiwada, Osaka, Japan. y.yonemura@coda.ocn.ne.jp
pubmed:publicationType
Journal Article