Linked Life Data

1969660

Source:http://linkedlifedata.com/resource/pubmed/id/1969660

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1239
pubmed:dateCreated
1990-5-8
pubmed:abstractText
Quiescent cultures of Swiss 3T3 cells can be stimulated to recommence deoxyribonucleic acid (DNA) synthesis by polypeptide growth factors, neuropeptides and various pharmacological agents that act via multiple signal transduction pathways. Neuropeptides of the bombesin family provide novel and potent mitogens to elucidate these pathways. The peptides bind to specific receptors that have been characterized by radioligand binding and sensitivity to antagonists and identified as glycoproteins of relative molecular mass (Mr) 75,000-85,000 by chemical cross-linking. After binding, bombesin elicits a cascade of early molecular events, including stimulation of phosphorylation of the acidic Mr 80,000 cellular protein (80,000) that is a major substrate of protein kinase C; Ca2+ mobilization mediated by Ins(1,4,5)P3; Na+ and K+ fluxes; transmodulation of (EGF) receptor; enhancement of cyclic adenosine monophosphate (cAMP) accumulation and expression of the proto-oncogenes c-fos and c-myc. Studies using digitonin-permeabilized 3T3 cells show that a G protein plays a role in the transduction of the mitogenic signal triggered by the binding of bombesin to its receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0962-8436
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
327
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Bombesin stimulation of fibroblast mitogenesis: specific receptors, signal transduction and early events.
pubmed:affiliation
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, U.K.
pubmed:publicationType
Journal Article, Comparative Study, Review