Source:http://linkedlifedata.com/resource/pubmed/id/19692203
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
We previously demonstrated that select cytokine gene polymorphisms in interleukin (IL)-8 are a significant predictor of pain and analgesia in patients with lung cancer. This study explores the role of 13 potentially functional polymorphisms in cytokine genes, including IL-1beta, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-alpha, and nuclear factor kappa-B subunit 1, in pain severity in patients with pancreatic cancer. We evaluated a series of patients with histologically confirmed adenocarcinoma of the pancreas (n=484), who had completed a self-administered survey of pain before initiating any cancer treatment. DNA (n=156) available for a subset of white patients was assayed and assessed for association with pain severity. Results showed that 26% (128 of 484) reported experiencing severe pain (score of >7 on a 0-10 scale). Severe pain varied by the stage of disease (odds ratio [OR] Stage II=4.02, 95% confidence interval (CI)=1.07, 15.07; Stage III=5.02, 95% CI=1.28, 19.61; Stage IV=6.90, 95% CI=1.96, 24.29), ethnicity (OR non-Hispanic blacks=3.67; 95% CI=1.44, 9.38), reports of depressed mood (OR=1.94; 95% CI=1.09, 3.43), and female sex (OR=1.78; 95% CI=1.04, 3.05). Controlling for these covariates, IL8-251T/A (OR=2.43, 95% CI=1.3, 4.7, P<0.009) significantly predicted severe pain in a subset of white patients. When we adjusted for reported analgesic use, we found that IL8-251T/A persisted as a predictor for severe pain, with carriers of TT and AT genotypes having more than a threefold risk (OR=3.23, 95% CI=1.4, 4.7) for severe pain relative to the AA genotypes. We provide preliminary evidence of the role of IL-8 in the severity of pain in pancreatic cancer patients. Additional studies are needed in larger cohorts of patients.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA101936,
http://linkedlifedata.com/resource/pubmed/grant/CA109043,
http://linkedlifedata.com/resource/pubmed/grant/CA128069,
http://linkedlifedata.com/resource/pubmed/grant/K07 CA109043-05,
http://linkedlifedata.com/resource/pubmed/grant/R03 CA128069-01A2
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1873-6513
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pubmed:author |
pubmed-author:AbbruzzeseJamesJ,
pubmed-author:BrueraEduardoE,
pubmed-author:CraneChristopher HCH,
pubmed-author:EvansDouglasD,
pubmed-author:FrazierMarshaM,
pubmed-author:KurzrockRazelleR,
pubmed-author:Reyes-GibbyCielito CCC,
pubmed-author:SheteSanjayS,
pubmed-author:SpitzMargaret RMR,
pubmed-author:YennurajalingamSriramS
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
894-902
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19692203-Adenocarcinoma,
pubmed-meshheading:19692203-Aged,
pubmed-meshheading:19692203-Analgesics,
pubmed-meshheading:19692203-Cytokines,
pubmed-meshheading:19692203-Drug Utilization,
pubmed-meshheading:19692203-False Positive Reactions,
pubmed-meshheading:19692203-Female,
pubmed-meshheading:19692203-Genetic Variation,
pubmed-meshheading:19692203-Humans,
pubmed-meshheading:19692203-Male,
pubmed-meshheading:19692203-Middle Aged,
pubmed-meshheading:19692203-Pain,
pubmed-meshheading:19692203-Pain Measurement,
pubmed-meshheading:19692203-Pancreatic Neoplasms,
pubmed-meshheading:19692203-Polymorphism, Single Nucleotide
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pubmed:year |
2009
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pubmed:articleTitle |
Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes.
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pubmed:affiliation |
Department of Epidemiology, Division of Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. creyes@mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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