19686743

Source:http://linkedlifedata.com/resource/pubmed/id/19686743

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0033325, umls-concept:C0033414, umls-concept:C0243125, umls-concept:C0332281, umls-concept:C0699900, umls-concept:C1325288, umls-concept:C1335831, umls-concept:C1425999, umls-concept:C2239176
pubmed:issue	5
pubmed:dateCreated	2009-10-26
pubmed:abstractText	The cell cycle regulators P21(WAF1), P27(KIP1), P57(KIP2), P130, RASSF1A, and FOXO1 are down-regulated during hepatocellular carcinoma (HCC) pathogenesis. We investigated the role of the ubiquitin ligase subunits CKS1 and SKP2, which regulate proteasome degradation of cell cycle regulators, in HCC progression.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374630
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CKS1B protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases, http://linkedlifedata.com/resource/pubmed/chemical/FOXO1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/RASSF1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/S-Phase Kinase-Associated Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1528-0012
pubmed:author	pubmed-author:BonelliPieroP, pubmed-author:CalvisiDiego FDF, pubmed-author:FeoFrancescoF, pubmed-author:FrauMaddalenaM, pubmed-author:HaweEmmaE, pubmed-author:LimDae-SikDS, pubmed-author:MuroniMaria RMR, pubmed-author:PascaleRosa MRM, pubmed-author:PinnaFedericoF, pubmed-author:SeddaiuMaria AMA, pubmed-author:SimileMaria MMM, pubmed-author:SiniMarcellaM, pubmed-author:TomasiMaria LML
pubmed:issnType	Electronic
pubmed:volume	137
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1816-26.e1-10
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:19686743-Carcinoma, Hepatocellular, pubmed-meshheading:19686743-Carrier Proteins, pubmed-meshheading:19686743-Cell Culture Techniques, pubmed-meshheading:19686743-Cell Cycle Proteins, pubmed-meshheading:19686743-Cell Line, Tumor, pubmed-meshheading:19686743-Cyclin-Dependent Kinase Inhibitor p21, pubmed-meshheading:19686743-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:19686743-Cyclin-Dependent Kinases, pubmed-meshheading:19686743-Forkhead Transcription Factors, pubmed-meshheading:19686743-Humans, pubmed-meshheading:19686743-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:19686743-Liver Neoplasms, pubmed-meshheading:19686743-S-Phase Kinase-Associated Proteins, pubmed-meshheading:19686743-Tumor Suppressor Proteins, pubmed-meshheading:19686743-Ubiquitination
pubmed:year	2009
pubmed:articleTitle	SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
pubmed:affiliation	Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't