Source:http://linkedlifedata.com/resource/pubmed/id/19681840
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2009-10-23
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| pubmed:abstractText |
Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification inhibitor and is expressed in bone, with not-yet well-defined functions. The aim of this study was to investigate the relation between bone mineral densitometry parameters, coronary artery calcification, and serum fetuin-A levels. In a cross-sectional design, we included 72 maintenance hemodialysis (HD) patients and 30 age- and gender-matched healthy controls. Serum fetuin-A levels were studied both in maintenance HD patients and healthy controls. Maintenance HD patients had radius, hip, and lumbar spine bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry and coronary artery calcification score (CACS) measured by electron-beam computed tomography. The associations between site-specific BMD parameters, CACS, and serum fetuin-A levels were studied in maintenance HD patients. CACS, mass, and volume of plaques in coronary arteries were significantly higher in patients with a T-score below -2.5 than above in the proximal region of the radius, neck and trochanter of the femur, and the lumbar spine. Mean serum fetuin-A concentration was 0.636 +/- 0.118 g/L in maintenance HD patients and it was less than healthy controls (0.829 +/- 0.100 g/L, P < 0.0001). CACS, mass, and volume of plaques in coronary arteries correlated significantly with the serum fetuin-A levels. Moreover, significant positive correlations were shown between the serum fetuin-A levels, BMD values, and T-scores of proximal radius, neck, and trochanter of the femur, but not with the lumbar spine. The present study demonstrates an association between serum fetuin-A levels, coronary artery calcification, and bone mineral densities--except for the lumbar spine, in maintenance HD patients. However, the results should be interpreted with caution because of the cross-sectional design of the study.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1525-1594
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
844-54
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19681840-Absorptiometry, Photon,
pubmed-meshheading:19681840-Adult,
pubmed-meshheading:19681840-Aged,
pubmed-meshheading:19681840-Biological Markers,
pubmed-meshheading:19681840-Blood Proteins,
pubmed-meshheading:19681840-Bone Density,
pubmed-meshheading:19681840-Calcinosis,
pubmed-meshheading:19681840-Case-Control Studies,
pubmed-meshheading:19681840-Coronary Artery Disease,
pubmed-meshheading:19681840-Cross-Sectional Studies,
pubmed-meshheading:19681840-Female,
pubmed-meshheading:19681840-Hip Joint,
pubmed-meshheading:19681840-Humans,
pubmed-meshheading:19681840-Kidney Failure, Chronic,
pubmed-meshheading:19681840-Lumbar Vertebrae,
pubmed-meshheading:19681840-Male,
pubmed-meshheading:19681840-Middle Aged,
pubmed-meshheading:19681840-Proportional Hazards Models,
pubmed-meshheading:19681840-Radius,
pubmed-meshheading:19681840-Renal Dialysis,
pubmed-meshheading:19681840-Risk Assessment,
pubmed-meshheading:19681840-Risk Factors,
pubmed-meshheading:19681840-Severity of Illness Index,
pubmed-meshheading:19681840-Tomography, X-Ray Computed,
pubmed-meshheading:19681840-alpha-2-HS-Glycoprotein
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| pubmed:year |
2009
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| pubmed:articleTitle |
Association among serum fetuin-A level, coronary artery calcification, and bone mineral densitometry in maintenance hemodialysis patients.
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| pubmed:affiliation |
Departments of Internal Medicine, Nephrology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey. alperkirkpantur@yahoo.com
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| pubmed:publicationType |
Journal Article
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