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| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0683971 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C1417701 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0802965 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0849974 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C1427969 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:19671143 | lifeskim:mentions | umls-concept:C0750729 | lld:lifeskim |
| pubmed-article:19671143 | pubmed:dateCreated | 2009-9-7 | lld:pubmed |
| pubmed-article:19671143 | pubmed:abstractText | The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema. We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population. | lld:pubmed |
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| pubmed-article:19671143 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19671143 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19671143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19671143 | pubmed:issn | 1465-993X | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:PostmaDirkje... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:BoezenH... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:SchoutenJan... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:SmitHenriette... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:BoerJolanda... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:19671143 | pubmed:author | pubmed-author:SiedlinskiMat... | lld:pubmed |
| pubmed-article:19671143 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19671143 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19671143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19671143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19671143 | pubmed:pagination | 73 | lld:pubmed |
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| pubmed-article:19671143 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19671143 | pubmed:articleTitle | Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. | lld:pubmed |
| pubmed-article:19671143 | pubmed:affiliation | Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.siedlinski@epi.umcg.nl | lld:pubmed |
| pubmed-article:19671143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19671143 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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