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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-9-7
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pubmed:abstractText |
The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induced emphysema. We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73
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pubmed:meshHeading |
pubmed-meshheading:19671143-Adult,
pubmed-meshheading:19671143-Aged,
pubmed-meshheading:19671143-Cohort Studies,
pubmed-meshheading:19671143-Female,
pubmed-meshheading:19671143-Genetic Predisposition to Disease,
pubmed-meshheading:19671143-Genetics, Population,
pubmed-meshheading:19671143-Humans,
pubmed-meshheading:19671143-Incidence,
pubmed-meshheading:19671143-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19671143-Male,
pubmed-meshheading:19671143-Maximal Expiratory Flow Rate,
pubmed-meshheading:19671143-Middle Aged,
pubmed-meshheading:19671143-NF-E2-Related Factor 2,
pubmed-meshheading:19671143-Netherlands,
pubmed-meshheading:19671143-Polymorphism, Single Nucleotide,
pubmed-meshheading:19671143-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:19671143-Risk Assessment,
pubmed-meshheading:19671143-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population.
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pubmed:affiliation |
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.siedlinski@epi.umcg.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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