Linked Life Data

19668114

Source:http://linkedlifedata.com/resource/pubmed/id/19668114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-11
pubmed:abstractText
Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here, we aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1473-5873
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-101
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.
pubmed:affiliation
Departments of aPsychiatry bRadiology, University of Bonn, Germany. Jessen@uni-bonn.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't