| pubmed-article:19666099 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0244988 | lld:lifeskim |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:19666099 | lifeskim:mentions | umls-concept:C0439825 | lld:lifeskim |
| pubmed-article:19666099 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:19666099 | pubmed:dateCreated | 2009-10-5 | lld:pubmed |
| pubmed-article:19666099 | pubmed:abstractText | Glycogen synthase kinase-3 (GSK-3) plays an important role in the regulation of apoptosis. However, the role of GSK-3 in the auditory system remains unknown. Here we examined whether the GSK-3-specific inhibitors, SB 216763 and LiCl, could protect against cisplatin-induced cytotoxicity of auditory cells. GSK-3 was activated by cisplatin treatment of HEI-OC1 cells. SB 216763 or LiCl treatments inhibited cisplatin-induced apoptosis in a dose-dependent manner and activated caspase-9, -8 and -3. In rat primary explants of the organ of Corti, SB 216763 or LiCl treatments completely abrogated the cisplatin-induced destruction of outer hair cell arrays. Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice. Furthermore, administration of SB 216763 or LiCl reduced the thresholds of the auditory brainstem response (ABR) in cisplatin-injected mice. Collectively, these results suggest that cisplatin-induced ototoxicity might be associated with modulation of GSK-3 activation. | lld:pubmed |
| pubmed-article:19666099 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19666099 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666099 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19666099 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19666099 | pubmed:issn | 1878-5891 | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:KwonKang-Beom... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:ParkCheung-Se... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:KimEun-KyungE... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:KimMin-SunMS | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:ParkSung-JooS... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:KimHyung-JinH... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:SeoSang-WanSW | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:ParkRae-KilRK | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:SongHo-JoonHJ | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:KimDo-YunDY | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:SongMi-YoungM... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:JungWon-SeokW... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:ParkHee-JeHJ | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:BaeGi-SangGS | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:HwangSung-Yeo... | lld:pubmed |
| pubmed-article:19666099 | pubmed:author | pubmed-author:ChongMyong-So... | lld:pubmed |
| pubmed-article:19666099 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19666099 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:19666099 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19666099 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19666099 | pubmed:pagination | 53-62 | lld:pubmed |
| pubmed-article:19666099 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:meshHeading | pubmed-meshheading:19666099... | lld:pubmed |
| pubmed-article:19666099 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19666099 | pubmed:articleTitle | Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells. | lld:pubmed |
| pubmed-article:19666099 | pubmed:affiliation | Department of Herbology, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea. tajohj82@hanmail.net | lld:pubmed |
| pubmed-article:19666099 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19666099 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:56637 | entrezgene:pubmed | pubmed-article:19666099 | lld:entrezgene |
| entrez-gene:84027 | entrezgene:pubmed | pubmed-article:19666099 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19666099 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19666099 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19666099 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19666099 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19666099 | lld:pubmed |
