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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-10-5
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pubmed:abstractText |
Glycogen synthase kinase-3 (GSK-3) plays an important role in the regulation of apoptosis. However, the role of GSK-3 in the auditory system remains unknown. Here we examined whether the GSK-3-specific inhibitors, SB 216763 and LiCl, could protect against cisplatin-induced cytotoxicity of auditory cells. GSK-3 was activated by cisplatin treatment of HEI-OC1 cells. SB 216763 or LiCl treatments inhibited cisplatin-induced apoptosis in a dose-dependent manner and activated caspase-9, -8 and -3. In rat primary explants of the organ of Corti, SB 216763 or LiCl treatments completely abrogated the cisplatin-induced destruction of outer hair cell arrays. Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice. Furthermore, administration of SB 216763 or LiCl reduced the thresholds of the auditory brainstem response (ABR) in cisplatin-injected mice. Collectively, these results suggest that cisplatin-induced ototoxicity might be associated with modulation of GSK-3 activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Maleimides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/SB 216763,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1878-5891
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pubmed:author |
pubmed-author:BaeGi-SangGS,
pubmed-author:ChongMyong-SooMS,
pubmed-author:HwangSung-YeonSY,
pubmed-author:JungWon-SeokWS,
pubmed-author:KimDo-YunDY,
pubmed-author:KimEun-KyungEK,
pubmed-author:KimHyung-JinHJ,
pubmed-author:KimMin-SunMS,
pubmed-author:KwonKang-BeomKB,
pubmed-author:ParkCheung-SeogCS,
pubmed-author:ParkHee-JeHJ,
pubmed-author:ParkRae-KilRK,
pubmed-author:ParkSung-JooSJ,
pubmed-author:SeoSang-WanSW,
pubmed-author:SongHo-JoonHJ,
pubmed-author:SongMi-YoungMY
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pubmed:issnType |
Electronic
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-62
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19666099-Acoustic Stimulation,
pubmed-meshheading:19666099-Animals,
pubmed-meshheading:19666099-Antineoplastic Agents,
pubmed-meshheading:19666099-Apoptosis,
pubmed-meshheading:19666099-Caspases,
pubmed-meshheading:19666099-Cell Line,
pubmed-meshheading:19666099-Cisplatin,
pubmed-meshheading:19666099-Disease Models, Animal,
pubmed-meshheading:19666099-Dose-Response Relationship, Drug,
pubmed-meshheading:19666099-Enzyme Activation,
pubmed-meshheading:19666099-Evoked Potentials, Auditory, Brain Stem,
pubmed-meshheading:19666099-Glycogen Synthase Kinase 3,
pubmed-meshheading:19666099-Hair Cells, Auditory,
pubmed-meshheading:19666099-Hearing Loss,
pubmed-meshheading:19666099-Indoles,
pubmed-meshheading:19666099-Injections, Intraperitoneal,
pubmed-meshheading:19666099-Interleukin-1beta,
pubmed-meshheading:19666099-Interleukin-6,
pubmed-meshheading:19666099-Lithium Chloride,
pubmed-meshheading:19666099-Maleimides,
pubmed-meshheading:19666099-Mice,
pubmed-meshheading:19666099-Mice, Inbred BALB C,
pubmed-meshheading:19666099-Mice, Inbred C57BL,
pubmed-meshheading:19666099-Organ Culture Techniques,
pubmed-meshheading:19666099-Organ of Corti,
pubmed-meshheading:19666099-Phosphorylation,
pubmed-meshheading:19666099-Protein Kinase Inhibitors,
pubmed-meshheading:19666099-Rats,
pubmed-meshheading:19666099-Rats, Sprague-Dawley,
pubmed-meshheading:19666099-Time Factors,
pubmed-meshheading:19666099-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells.
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pubmed:affiliation |
Department of Herbology, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea. tajohj82@hanmail.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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