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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-23
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pubmed:abstractText |
Hepatic ischemia/reperfusion (I/R) injury is a pathologic process caused by hepatic surgery and transplantation, and still remains a severe clinical problem. It was shown that preconditioning by hyperthermia might protect tissues against I/R injury. But hyperthermia could be laborious and time-consuming. Alternatively, the application of mild electrical stimulation (MES) has been reported to have positive effects in clinical settings on several medical ailments. Thus, we modified the preconditioning approach by combining short-term mild heat shock (HS) and MES, and evaluated the effect of HS+MES pretreatment on hepatic injury induced by I/R.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-20
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pubmed:meshHeading |
pubmed-meshheading:19665146-Alanine Transaminase,
pubmed-meshheading:19665146-Animals,
pubmed-meshheading:19665146-Aspartate Aminotransferases,
pubmed-meshheading:19665146-Cytokines,
pubmed-meshheading:19665146-DNA Primers,
pubmed-meshheading:19665146-Electric Stimulation,
pubmed-meshheading:19665146-Gene Amplification,
pubmed-meshheading:19665146-Gene Expression Regulation,
pubmed-meshheading:19665146-HSP72 Heat-Shock Proteins,
pubmed-meshheading:19665146-Hot Temperature,
pubmed-meshheading:19665146-Ischemia,
pubmed-meshheading:19665146-Liver,
pubmed-meshheading:19665146-Liver Circulation,
pubmed-meshheading:19665146-Liver Transplantation,
pubmed-meshheading:19665146-Male,
pubmed-meshheading:19665146-Mice,
pubmed-meshheading:19665146-Mice, Inbred C57BL,
pubmed-meshheading:19665146-Postoperative Complications,
pubmed-meshheading:19665146-Reperfusion Injury,
pubmed-meshheading:19665146-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Modified mild heat shock modality attenuates hepatic ischemia/reperfusion injury.
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pubmed:affiliation |
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Kumamoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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