Linked Life Data

19660458

Source:http://linkedlifedata.com/resource/pubmed/id/19660458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2009-9-1
pubmed:abstractText
Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1873-3468
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
583
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2882-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes.
pubmed:affiliation
Department of Diabetes and Endocrinology, Gifu University, Graduate School of Medicine, Gifu, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't