| pubmed-article:19659774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C2362651 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1540292 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:19659774 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:19659774 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19659774 | pubmed:dateCreated | 2009-8-7 | lld:pubmed |
| pubmed-article:19659774 | pubmed:abstractText | Human immunodeficiency virus (HIV)-1 causes T cell anergy and affects T cell maturation. Various mechanisms are responsible for impaired anti-HIV-1-specific responses: programmed death (PD)-1 molecule and its ligand PD-L1 are negative regulators of T cell activity and their expression is increased during HIV-1 infection. This study examines correlations between T cell maturation, expression of PD-1 and PD-L1, and the effects of their blockade. Peripheral blood mononuclear cells (PBMC) from 24 HIV-1(+) and 17 uninfected individuals were phenotyped for PD-1 and PD-L1 expression on CD4(+) and CD8(+) T cell subsets. The effect of PD-1 and PD-L1 blockade on proliferation and interferon (IFN)-gamma production was tested on eight HIV-1(+) patients. Naive (CCR7(+)CD45RA(+)) CD8(+) T cells were reduced in HIV-1 aviraemic (P = 0.0065) and viraemic patients (P = 0.0130); CD8 T effector memory subsets [CCR7(-)CD45RA(-)(T(EM))] were increased in HIV-1(+) aviraemic (P = 0.0122) and viraemic (P = 0.0023) individuals versus controls. PD-1 expression was increased in CD4 naive (P = 0.0496), central memory [CCR7(+)CD45RA(-) (T(CM)); P = 0.0116], T(EM) (P = 0.0037) and CD8 naive T cells (P = 0.0133) of aviraemic HIV-1(+) versus controls. PD-L1 was increased in CD4 T(EMRA) (CCR7(-)CD45RA(+), P = 0.0119), CD8 T(EM) (P = 0.0494) and CD8 T(EMRA) (P = 0.0282) of aviraemic HIV-1(+)versus controls. PD-1 blockade increased HIV-1-specific proliferative responses in one of eight patients, whereas PD-L1 blockade restored responses in four of eight patients, but did not increase IFN-gamma-production. Alteration of T cell subsets, accompanied by increased PD-1 and PD-L1 expression in HIV-1 infection contributes to anergy and impaired anti-HIV-1-specific responses which are not rescued when PD-1 is blocked, in contrast to when PD-L1 is blocked, due possibly to an ability to bind to receptors other than PD-1. | lld:pubmed |
| pubmed-article:19659774 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19659774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19659774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19659774 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19659774 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:19659774 | pubmed:author | pubmed-author:LimC HCH | lld:pubmed |
| pubmed-article:19659774 | pubmed:author | pubmed-author:GotchFF | lld:pubmed |
| pubmed-article:19659774 | pubmed:author | pubmed-author:BowenII | lld:pubmed |
| pubmed-article:19659774 | pubmed:author | pubmed-author:ImamiNN | lld:pubmed |
| pubmed-article:19659774 | pubmed:author | pubmed-author:RosignoliGG | lld:pubmed |
| pubmed-article:19659774 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19659774 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:19659774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19659774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19659774 | pubmed:pagination | 90-7 | lld:pubmed |
| pubmed-article:19659774 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19659774 | pubmed:meshHeading | pubmed-meshheading:19659774... | lld:pubmed |
| pubmed-article:19659774 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19659774 | pubmed:articleTitle | Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals. | lld:pubmed |
| pubmed-article:19659774 | pubmed:affiliation | Department of Immunology, Imperial College London, Chelsea & Westminster Hospital, London, UK. | lld:pubmed |
| pubmed-article:19659774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19659774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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