Linked Life Data

19659774

Source:http://linkedlifedata.com/resource/pubmed/id/19659774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-8-7
pubmed:abstractText
Human immunodeficiency virus (HIV)-1 causes T cell anergy and affects T cell maturation. Various mechanisms are responsible for impaired anti-HIV-1-specific responses: programmed death (PD)-1 molecule and its ligand PD-L1 are negative regulators of T cell activity and their expression is increased during HIV-1 infection. This study examines correlations between T cell maturation, expression of PD-1 and PD-L1, and the effects of their blockade. Peripheral blood mononuclear cells (PBMC) from 24 HIV-1(+) and 17 uninfected individuals were phenotyped for PD-1 and PD-L1 expression on CD4(+) and CD8(+) T cell subsets. The effect of PD-1 and PD-L1 blockade on proliferation and interferon (IFN)-gamma production was tested on eight HIV-1(+) patients. Naive (CCR7(+)CD45RA(+)) CD8(+) T cells were reduced in HIV-1 aviraemic (P = 0.0065) and viraemic patients (P = 0.0130); CD8 T effector memory subsets [CCR7(-)CD45RA(-)(T(EM))] were increased in HIV-1(+) aviraemic (P = 0.0122) and viraemic (P = 0.0023) individuals versus controls. PD-1 expression was increased in CD4 naive (P = 0.0496), central memory [CCR7(+)CD45RA(-) (T(CM)); P = 0.0116], T(EM) (P = 0.0037) and CD8 naive T cells (P = 0.0133) of aviraemic HIV-1(+) versus controls. PD-L1 was increased in CD4 T(EMRA) (CCR7(-)CD45RA(+), P = 0.0119), CD8 T(EM) (P = 0.0494) and CD8 T(EMRA) (P = 0.0282) of aviraemic HIV-1(+)versus controls. PD-1 blockade increased HIV-1-specific proliferative responses in one of eight patients, whereas PD-L1 blockade restored responses in four of eight patients, but did not increase IFN-gamma-production. Alteration of T cell subsets, accompanied by increased PD-1 and PD-L1 expression in HIV-1 infection contributes to anergy and impaired anti-HIV-1-specific responses which are not rescued when PD-1 is blocked, in contrast to when PD-L1 is blocked, due possibly to an ability to bind to receptors other than PD-1.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-10358770, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-10537110, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-11242051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-11595291, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-11986671, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-12186885, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-12351945, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-12468426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-12605694, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-12958069, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-15265956, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-16382236, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-16520776, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-16917489, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-16921384, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-16954372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-17168707, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-17428345, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-17545722, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-17885290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-18173375, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-18440040, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-18585785, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-18650129, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-7688139, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-8752911, http://linkedlifedata.com/resource/pubmed/commentcorrection/19659774-9367954
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1365-2249
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19659774-Antigens, CD, pubmed-meshheading:19659774-Antigens, CD274, pubmed-meshheading:19659774-Apoptosis Regulatory Proteins, pubmed-meshheading:19659774-CD4-Positive T-Lymphocytes, pubmed-meshheading:19659774-CD8-Positive T-Lymphocytes, pubmed-meshheading:19659774-Case-Control Studies, pubmed-meshheading:19659774-Cell Proliferation, pubmed-meshheading:19659774-Flow Cytometry, pubmed-meshheading:19659774-HIV Infections, pubmed-meshheading:19659774-HIV-1, pubmed-meshheading:19659774-Humans, pubmed-meshheading:19659774-Immunophenotyping, pubmed-meshheading:19659774-Interferon-gamma, pubmed-meshheading:19659774-Lymphocyte Count, pubmed-meshheading:19659774-Programmed Cell Death 1 Receptor, pubmed-meshheading:19659774-T-Lymphocyte Subsets, pubmed-meshheading:19659774-Viral Load
pubmed:year
2009
pubmed:articleTitle
Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals.
pubmed:affiliation
Department of Immunology, Imperial College London, Chelsea & Westminster Hospital, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't