Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2009-10-2
pubmed:databankReference
pubmed:abstractText
The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We conclude that MICA may represent novel a transplantation antigen recognized by human allogeneic T cells. This study was registered at ClinicalTrials.gov (Identifier NCT00506922).
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2884-7
pubmed:meshHeading
pubmed-meshheading:19654407-Adolescent, pubmed-meshheading:19654407-Adult, pubmed-meshheading:19654407-Aged, pubmed-meshheading:19654407-Blood Donors, pubmed-meshheading:19654407-Female, pubmed-meshheading:19654407-Genes, MHC Class I, pubmed-meshheading:19654407-Genotype, pubmed-meshheading:19654407-Graft Rejection, pubmed-meshheading:19654407-Graft vs Host Disease, pubmed-meshheading:19654407-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:19654407-Histocompatibility, pubmed-meshheading:19654407-Histocompatibility Testing, pubmed-meshheading:19654407-Humans, pubmed-meshheading:19654407-Incidence, pubmed-meshheading:19654407-Leukemia, Myeloid, Acute, pubmed-meshheading:19654407-Male, pubmed-meshheading:19654407-Middle Aged, pubmed-meshheading:19654407-Prognosis, pubmed-meshheading:19654407-Prospective Studies, pubmed-meshheading:19654407-Risk Factors, pubmed-meshheading:19654407-Survival Rate, pubmed-meshheading:19654407-Treatment Outcome, pubmed-meshheading:19654407-Young Adult
pubmed:year
2009
pubmed:articleTitle
Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease.
pubmed:affiliation
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article