Linked Life Data

19651198

Source:http://linkedlifedata.com/resource/pubmed/id/19651198

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-6-14
pubmed:abstractText
Molecular changes caused by sensory trauma and subsequent structural alterations of the central nervous system are only beginning to be identified. In most cases, the generation of tinnitus can be linked to damage of the peripheral auditory system, probably even in cases where hearing impairment cannot be assessed by audiometry. Within a common view, acoustic trauma and salicylate induce abnormal excitability at the level of the brainstem, subcortical and cortical level that may be related to tinnitus. The present review summarizes studies emphasizing a crucial role of molecular events that occur in the cochlea exhibiting the potential to alter the network activity in distinct areas of the brain, including the limbic system. We proceed from the inner ear to the auditory cortex and discuss the recent molecular findings in the central auditory system as a secondary step of previous neuronal changes in the periphery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1878-5891
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Molecular aspects of tinnitus.
pubmed:affiliation
Department of Otorhinolaryngology, University of Tübingen, Hearing Research Centre Tübingen (THRC), Molecular Neurobiology & Cell Biology of the Inner Ear, Elfriede-Aulhorn-Strasse 5, D-72076 Tübingen, Germany. marlies.knipper@uni-tuebingen.de <marlies.knipper@uni-tuebingen.de>
pubmed:publicationType
Journal Article, Review