| pubmed-article:19648268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:19648268 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:19648268 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19648268 | pubmed:dateCreated | 2009-8-21 | lld:pubmed |
| pubmed-article:19648268 | pubmed:abstractText | It is known that C3 is required for optimal expansion of T cells during acute viral infections. However, it is not yet determined whether T cell responses to intracellular bacterial infections require C3. Therefore, we have investigated the requirement for C3 to elicit potent T cell responses to Listeria monocytogenes (LM). We show that expansion of Ag-specific CD8 and CD4 T cells during a primary response to LM was markedly reduced in the absence of C3 activity. Further studies indicated that, unlike in an influenza virus infection, the regulation of LM-specific T cell responses by C3 might not involve the downstream effector C5a. Moreover, reduced T cell responses to LM was not linked to defective maturation of dendritic cells or developmental anomalies in the peripheral T cell compartment of C3-deficient mice. Experiments involving adoptive transfer of C3-deficient CD8 T cells into the C3-sufficient environment of wild-type mice showed that these T cells do not have intrinsic proliferative defects, and a paracrine source of C3 will suffice for clonal expansion of CD8 T cells in vivo. However, stimulation of purified C3-deficient CD8 T cells by plastic-immobilized anti-CD3 showed that C3 promotes T cell proliferation directly, independent of its effects on APC. On the basis of these findings, we propose that diminished T cell responses to LM in C3-deficient mice might be at least in part due to lack of direct effects of C3 on T cells. These studies have furthered our understanding of C3-mediated regulation of T cell immunity to intracellular pathogens. | lld:pubmed |
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| pubmed-article:19648268 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19648268 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19648268 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19648268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19648268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19648268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19648268 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19648268 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:SureshMM | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:KimEui HoEH | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:LambrisJohn... | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:SandorMatyasM | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:NakayamaYumiY | lld:pubmed |
| pubmed-article:19648268 | pubmed:author | pubmed-author:KimShin-IlSI | lld:pubmed |
| pubmed-article:19648268 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19648268 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19648268 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:19648268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19648268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19648268 | pubmed:pagination | 2921-31 | lld:pubmed |
| pubmed-article:19648268 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:19648268 | pubmed:meshHeading | pubmed-meshheading:19648268... | lld:pubmed |
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| pubmed-article:19648268 | pubmed:meshHeading | pubmed-meshheading:19648268... | lld:pubmed |
| pubmed-article:19648268 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19648268 | pubmed:articleTitle | C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection. | lld:pubmed |
| pubmed-article:19648268 | pubmed:affiliation | Department of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA. | lld:pubmed |
| pubmed-article:19648268 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19648268 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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