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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Risk alleles for age-related diseases are expected to decrease in frequency in the population strata of increasing age. Consistent with this hypothesis, earlier studies showed a depletion of the Alzheimer's disease risk factor APOE*epsilon4 in long-lived individuals (LLIs). To evaluate whether this observation also holds for a previously suggested Alzheimer's disease risk haplotype in the A2M gene, we analyzed this particular haplotype in 1042 German LLIs (aged 95-100 years) and 1040 younger individuals (aged 60-75 years). Our results show a significant depletion of this haplotype in LLIs, thus confirming it as a mortality factor in the elderly. Consequently, our data support an involvement of the suggested A2M risk haplotype in the pathogenesis of Alzheimer's disease and adds new evidence to the risk-allele depletion hypothesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-10466675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-10980733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-11791212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-11965171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12028221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12175343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12634289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12653662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12916020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-12966032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-16183100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-16708071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-17701901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-8346443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-9697696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19639019-9811940
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1476-5438
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-61
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.
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pubmed:affiliation |
Institute of Clinical Molecular Biology, Christian-Albrechts University and University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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