| pubmed-article:19637874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0003392 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0077274 | lld:lifeskim |
| pubmed-article:19637874 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:19637874 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:19637874 | pubmed:dateCreated | 2010-6-21 | lld:pubmed |
| pubmed-article:19637874 | pubmed:abstractText | It has long been considered that the free beta hydroxyl group at C14 of triptolide (1) is essential to its potent anticancer activity. In this study, we synthesized novel derivatives of 1 with a hydroxyl group substituted by epoxy groups (4-8) or a five-membered ring (11-13). Compounds (4-8) showed significant in vitro anticancer activity although less potent than 1. Although with an alpha oxygen configuration at the C14 position, (14S)-14,21-epoxytriptolide (4) exhibited the highest potency among all these derivatives, clearly challenging the traditional viewpoint on the necessity of C14beta-hydroxyl group of compound 1. Further studies revealed that while displaying broad spectrum in vitro anticancer activity, compound 4 demonstrated prominent selective in vivo anticancer activity, particularly against human ovarian SK-OV-3 and prostate PC-3 cancers with obviously lower toxicity than 1. Noticeably, compound 4 was also highly effective against multidrug resistant cancer cells. Therefore, our study gives new insights into the structure-activity relationship of 1 and also produces a promising anticancer drug candidate with unique anticancer activities. | lld:pubmed |
| pubmed-article:19637874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19637874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19637874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19637874 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19637874 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:LiZhengZ | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:DingJianJ | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:MiaoZe-HongZH | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:TongLin-Jiang... | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:LiYuan-ChaoYC | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:LinLi-PingLP | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:ZhouZhao-LiZL | lld:pubmed |
| pubmed-article:19637874 | pubmed:author | pubmed-author:FengHui-JinHJ | lld:pubmed |
| pubmed-article:19637874 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19637874 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:19637874 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19637874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19637874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19637874 | pubmed:pagination | 5115-23 | lld:pubmed |
| pubmed-article:19637874 | pubmed:meshHeading | pubmed-meshheading:19637874... | lld:pubmed |
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| pubmed-article:19637874 | pubmed:meshHeading | pubmed-meshheading:19637874... | lld:pubmed |
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| pubmed-article:19637874 | pubmed:meshHeading | pubmed-meshheading:19637874... | lld:pubmed |
| pubmed-article:19637874 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19637874 | pubmed:articleTitle | Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents. | lld:pubmed |
| pubmed-article:19637874 | pubmed:affiliation | Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. | lld:pubmed |
| pubmed-article:19637874 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19637874 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19637874 | lld:chembl |
