Source:http://linkedlifedata.com/resource/pubmed/id/19637868
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
32
|
| pubmed:dateCreated |
2009-9-2
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| pubmed:abstractText |
A nickel-catalyzed intermolecular hydroacylation of methylenecyclopropanes (MCPs) has been developed. The reaction proceeds with stereospecific cleavage of the proximal C-C bond of the cyclopropane ring to give gamma,delta-unsaturated ketones with high diastereoselectivities. A nickel catalyst generated in situ from Ni(cod)(2) and P(n-Bu)(3) with a P/Ni ratio of 1:1 is effective for the hydroacylation, in which benzaldehyde derivatives, heteroaryl aldehydes, and aliphatic aldehydes react with MCPs at 60-100 degrees C to afford the corresponding ketones in high yields.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1520-5126
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
19
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11298-9
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| pubmed:year |
2009
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| pubmed:articleTitle |
Nickel-catalyzed ring-opening hydroacylation of methylenecyclopropanes: synthesis of gamma,delta-unsaturated ketones from aldehydes.
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| pubmed:affiliation |
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
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| pubmed:publicationType |
Journal Article
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