|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0026882,
umls-concept:C0030946,
umls-concept:C0087111,
umls-concept:C0205314,
umls-concept:C0231174,
umls-concept:C0292818,
umls-concept:C0674432,
umls-concept:C0679622,
umls-concept:C0683598,
umls-concept:C1511253,
umls-concept:C1704259,
umls-concept:C1705987
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2009-8-6
|
|
pubmed:abstractText |
Virological failure of first-line antiretroviral therapy based on lopinavir boosted with ritonavir (lopinavir/r) has rarely been associated with resistance in protease. We identified a new genotypic resistance pathway in 3 patients who experienced failure of first-line lopinavir/r treatment.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
200
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
698-709
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19627247-Amino Acid Sequence,
pubmed-meshheading:19627247-Amino Acid Substitution,
pubmed-meshheading:19627247-Anti-HIV Agents,
pubmed-meshheading:19627247-DNA Mutational Analysis,
pubmed-meshheading:19627247-Drug Resistance, Viral,
pubmed-meshheading:19627247-HIV,
pubmed-meshheading:19627247-HIV Infections,
pubmed-meshheading:19627247-HIV Protease,
pubmed-meshheading:19627247-Humans,
pubmed-meshheading:19627247-Longitudinal Studies,
pubmed-meshheading:19627247-Lopinavir,
pubmed-meshheading:19627247-Molecular Sequence Data,
pubmed-meshheading:19627247-Mutation, Missense,
pubmed-meshheading:19627247-Phylogeny,
pubmed-meshheading:19627247-Pyrimidinones,
pubmed-meshheading:19627247-Ritonavir,
pubmed-meshheading:19627247-Sequence Analysis, DNA,
pubmed-meshheading:19627247-Sequence Homology,
pubmed-meshheading:19627247-Treatment Failure,
pubmed-meshheading:19627247-Virus Replication,
pubmed-meshheading:19627247-gag Gene Products, Human Immunodeficiency Virus
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V.
|
|
pubmed:affiliation |
Department of Medical Microbiology, Division of General Medicine, Infectious Diseases and Geriatrics, University Medical Center Utrecht, Utrecht, the Netherlands. m.nijhuis@umcutrecht.nl
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|
pubmed:publicationType |
Journal Article,
Case Reports
|
