Source:http://linkedlifedata.com/resource/pubmed/id/19627175
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2009-7-24
|
| pubmed:abstractText |
Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are most frequently used drugs in the prevention of coronary artery disease due to their cholesterol-lowering activity. However, it is not exactly known whether these effects of statins or those independent of cholesterol decrease account for the protection against myocardial ischemia-reperfusion (I/R) injury. In this study, we investigated the effect of 5-day treatment with simvastatin (10 mg/kg) in Langendorff-perfused hearts of healthy control (C) and diabetic-hypercholesterolemic (D-H; streptozotocin + high fat-cholesterol diet, 5 days) rats subjected to 30-min global ischemia followed by 40-min reperfusion for the examination of postischemic contractile dysfunction and reperfusion-induced ventricular arrhythmias or to 30-min (left anterior descending) coronary artery occlusion and 2-h reperfusion for the infarct size determination (IS; tetrazolium staining). Postischemic recovery of left ventricular developed pressure (LVDP) in animals with D-H was improved by simvastatin therapy (62.7+/-18.2 % of preischemic values vs. 30.3+/-5.7 % in the untreated D-H; P<0.05), similar to the values in the simvastatin-treated C group, which were 2.5-fold higher than those in the untreated C group. No ventricular fibrillation occurred in the simvastatin-treated C and D-H animals during reperfusion. Likewise, simvastatin shortened the duration of ventricular tachycardia (10.2+/-8.1 s and 57.8+/-29.3 s in C and D-H vs. 143.6+/-28.6 s and 159.3+/-44.3 s in untreated C and D-H, respectively, both P<0.05). The decreased arrhythmogenesis in the simvastatin-treated groups correlated with the limitation of IS (in % of risk area) by 66 % and 62 % in C and D-H groups, respectively. However, simvastatin treatment decreased plasma cholesterol levels neither in the D-H animals nor in C. The results indicate that other effects of statins (independent of cholesterol lowering) are involved in the improvement of contractile recovery and attenuation of lethal I/R injury in both, healthy and diseased individuals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0862-8408
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
449-54
|
| pubmed:meshHeading |
pubmed-meshheading:19627175-Animals,
pubmed-meshheading:19627175-Arrhythmias, Cardiac,
pubmed-meshheading:19627175-Cardiotonic Agents,
pubmed-meshheading:19627175-Cholesterol,
pubmed-meshheading:19627175-Diabetes Mellitus, Experimental,
pubmed-meshheading:19627175-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:19627175-Hypercholesterolemia,
pubmed-meshheading:19627175-Male,
pubmed-meshheading:19627175-Myocardial Contraction,
pubmed-meshheading:19627175-Myocardial Infarction,
pubmed-meshheading:19627175-Myocardial Ischemia,
pubmed-meshheading:19627175-Myocardium,
pubmed-meshheading:19627175-Perfusion,
pubmed-meshheading:19627175-Rats,
pubmed-meshheading:19627175-Rats, Wistar,
pubmed-meshheading:19627175-Recovery of Function,
pubmed-meshheading:19627175-Simvastatin,
pubmed-meshheading:19627175-Ventricular Pressure
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Simvastatin alleviates myocardial contractile dysfunction and lethal ischemic injury in rat heart independent of cholesterol-lowering effects.
|
| pubmed:affiliation |
1Department of Pharmacology and Toxicology, Facultyof Pharmacy Comenius University, Bratislava, Slovak Republic.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|