Linked Life Data

19622841

Source:http://linkedlifedata.com/resource/pubmed/id/19622841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-14
pubmed:abstractText
Together, thousands of neurons with similar function make up topographically oriented sensory cortex maps that represent contralateral body parts. Although this is an accepted model for the adult cortex, whether these same rules hold after stroke-induced damage is unclear. After stroke, sensory representations damaged by stroke remap onto nearby surviving neurons. Here, we review the process of sensory remapping after stroke at multiple levels ranging from the initial damage to synapses, to their rewiring and function in intact sensory circuits. We introduce a new approach using in vivo 2-photon calcium imaging to determine how the response properties of individual somatosensory cortex neurons are altered during remapping. One month after forelimb-area stroke, normally highly limb-selective neurons in surviving peri-infarct areas exhibit remarkable flexibility and begin to process sensory stimuli from multiple limbs as remapping proceeds. Two months after stroke, neurons within remapped regions develop a stronger response preference. Thus, remapping is initiated by surviving neurons adopting new roles in addition to their usual function. Later in recovery, these remapped forelimb-responsive neurons become more selective, but their new topographical representation may encroach on map territories of neurons that process sensory stimuli from other body parts. Neurons responding to multiple limbs may reflect a transitory phase in the progression from their involvement in one sensorimotor function to a new function that replaces processing lost due to stroke.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1089-4098
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-24
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Remapping the somatosensory cortex after stroke: insight from imaging the synapse to network.
pubmed:affiliation
Department of Psychiatry (NRU), Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't