Source:http://linkedlifedata.com/resource/pubmed/id/19617843
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2009-8-14
|
| pubmed:abstractText |
The increasing availability of personal genomic tests has led to discussions about the validity and utility of such tests and the balance of benefits and harms. A multidisciplinary workshop was convened by the National Institutes of Health and the Centers for Disease Control and Prevention to review the scientific foundation for using personal genomics in risk assessment and disease prevention and to develop recommendations for targeted research. The clinical validity and utility of personal genomics is a moving target with rapidly developing discoveries but little translation research to close the gap between discoveries and health impact. Workshop participants made recommendations in five domains: (1) developing and applying scientific standards for assessing personal genomic tests; (2) developing and applying a multidisciplinary research agenda, including observational studies and clinical trials to fill knowledge gaps in clinical validity and utility; (3) enhancing credible knowledge synthesis and information dissemination to clinicians and consumers; (4) linking scientific findings to evidence-based recommendations for use of personal genomics; and (5) assessing how the concept of personal utility can affect health benefits, costs, and risks by developing appropriate metrics for evaluation. To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed.
|
| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/K24 AG027841-01A1,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000533-360391,
http://linkedlifedata.com/resource/pubmed/grant/P30 AG013846-069001,
http://linkedlifedata.com/resource/pubmed/grant/R01 HG002213-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 HG005092-01A1
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1530-0366
|
| pubmed:author |
pubmed-author:BernhardtJay MJM,
pubmed-author:CargillMicheleM,
pubmed-author:Centers for Disease Control and Prevention,
pubmed-author:ChanockStephen JSJ,
pubmed-author:ChurchGeorge MGM,
pubmed-author:CoatesRalph JRJ,
pubmed-author:CollinsFrancis SFS,
pubmed-author:CroyleRobert TRT,
pubmed-author:DavisBarry RBR,
pubmed-author:DowningGregory JGJ,
pubmed-author:DurossAmyA,
pubmed-author:FeeroW GregoryWG,
pubmed-author:FriedmanSusanS,
pubmed-author:GailMitchell HMH,
pubmed-author:GinsburgGeoffrey SGS,
pubmed-author:GreenRobert CRC,
pubmed-author:GreeneMark HMH,
pubmed-author:GreenlandPhilipP,
pubmed-author:GulcherJeffrey RJR,
pubmed-author:GwinnMartaM,
pubmed-author:HsuAndroA,
pubmed-author:HudsonKathy LKL,
pubmed-author:IoannidisJohn P AJP,
pubmed-author:JanssensA Cecile J WAC,
pubmed-author:KardiaSharon L RSL,
pubmed-author:KhouryMuin JMJ,
pubmed-author:KimmelPaul LPL,
pubmed-author:LauerMichael SMS,
pubmed-author:McBrideColleen MCM,
pubmed-author:MillerAmy MAM,
pubmed-author:OffitKennethK,
pubmed-author:RansohoffDavid FDF,
pubmed-author:RasoolyRebekah SRS,
pubmed-author:RobertsJ ScottJS,
pubmed-author:SchullySheri DSD,
pubmed-author:Simons-MortonDenise GDG,
pubmed-author:StefanssonKariK,
pubmed-author:TerrySharon FSF,
pubmed-author:TeutschSteven MSM,
pubmed-author:TrepanierAngelaA,
pubmed-author:WankeKay LKL,
pubmed-author:WitteJohn SJS,
pubmed-author:XuJianfengJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
559-67
|
| pubmed:dateRevised |
2011-5-5
|
| pubmed:meshHeading | |
| pubmed:year |
2009
|
| pubmed:articleTitle |
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop.
|
| pubmed:affiliation |
Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. mkhoury@cdc.gov
|
| pubmed:publicationType |
Journal Article,
Guideline,
Consensus Development Conference, NIH
|