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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-9-14
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pubmed:abstractText |
Perivascular and meningeal macrophages are important for immune surveillance in the healthy and the injured brain. Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage migration and permeability of the blood brain barrier. In the present study, we investigated the influence of MCP-1 or/and chemokine receptor 2 (CCR2)-deficiency on macrophage turnover. The results showed no influence of single MCP-1- or CCR-2-deficiency, but double-deficient mice revealed a virtual absence of blood-borne macrophage recruitment. This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1090-2430
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
219
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
583-5
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pubmed:meshHeading |
pubmed-meshheading:19615366-Animals,
pubmed-meshheading:19615366-Antigens, Differentiation,
pubmed-meshheading:19615366-Chemokine CCL2,
pubmed-meshheading:19615366-Green Fluorescent Proteins,
pubmed-meshheading:19615366-Macrophages,
pubmed-meshheading:19615366-Meninges,
pubmed-meshheading:19615366-Mice,
pubmed-meshheading:19615366-Mice, Inbred C57BL,
pubmed-meshheading:19615366-Mice, Knockout,
pubmed-meshheading:19615366-Receptors, CCR2
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pubmed:year |
2009
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pubmed:articleTitle |
Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice.
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pubmed:affiliation |
Department of Neurology, University Hospital Münster, Münster, Germany. schillim@uni-muenster.de
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pubmed:publicationType |
Journal Article
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