Linked Life Data

19614979

Source:http://linkedlifedata.com/resource/pubmed/id/19614979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-8-7
pubmed:abstractText
This study examined the role of dopamine within the amygdala (AMY) in flavor preference learning induced by post-oral glucose. In Experiment 1, rats were trained with a flavor [conditioned stimulus (CS+)] paired with intragastric (IG) infusions of 8% glucose and a different flavor (CS-) paired with IG water infusions. The CS+ preference was evaluated in two-bottle tests following bilateral injection of the dopamine D1-like receptor antagonist, SCH23390 (SCH), into the AMY at total doses of 0, 12, 24 and 48 nmol. SCH produced dose-dependent reductions in CS+ intake but did not block the CS+ preference except at the two highest doses, which also greatly suppressed the CS intakes. In Experiment 2, new rats were injected daily in the AMY with either saline or SCH (12 nmol), prior to training sessions with CS+/IG glucose and CS-/IG water. In the two-bottle tests, SCH rats, unlike the control rats, failed to prefer the CS+ (55 vs. 81%). In Experiments 3 and 4, new rats were trained as in Experiment 2, except that brain injections were in the basolateral and central nuclei of the AMY, respectively. SCH rats learned to prefer the CS+ to the CS-, although their preference was weaker than that displayed by the control rats (Experiment 3: 59 vs. 80%; Experiment 4: 73 vs. 88%). These results show an essential role for D1-like receptor activation in the AMY in the acquisition of flavor preference learning induced by the post-oral reinforcing properties of glucose. A distributed network mediating flavor-nutrient incentive learning is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1460-9568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-98
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Dopamine D1-like receptor antagonism in amygdala impairs the acquisition of glucose-conditioned flavor preference in rats.
pubmed:affiliation
Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA. ktouzani@brooklyn.cuny.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural