|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0021311,
umls-concept:C0030705,
umls-concept:C0085436,
umls-concept:C0085862,
umls-concept:C0205195,
umls-concept:C0205210,
umls-concept:C0449297,
umls-concept:C0599755,
umls-concept:C0936012,
umls-concept:C1274040,
umls-concept:C1299583,
umls-concept:C1521828,
umls-concept:C1549571,
umls-concept:C1608386
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2009-8-5
|
|
pubmed:abstractText |
Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of clearance of infection, based on serial quantitative cultures of cerebrospinal fluid, to differentiate the fungicidal activity of alternative antifungal drug regimens. We hypothesized that the rate of clearance of infection should also be a clinically meaningful endpoint.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1537-6591
|
|
pubmed:author |
pubmed-author:BekkerLinda-GailLG,
pubmed-author:BicanicTihanaT,
pubmed-author:BrouwerAnnemarie EAE,
pubmed-author:ChierakulWirongrongW,
pubmed-author:HarrisonThomas STS,
pubmed-author:JaffarShabbarS,
pubmed-author:JarvisJosephJ,
pubmed-author:LimmathurotsakulDirekD,
pubmed-author:LongleyNickyN,
pubmed-author:LoyseAngelaA,
pubmed-author:MeintjesGraemeG,
pubmed-author:MuzooraConradC,
pubmed-author:RebeKevinK,
pubmed-author:StepniewskaKasiaK,
pubmed-author:TaseeraKabandaK,
pubmed-author:WhiteNicholas JNJ,
pubmed-author:WoodRobinR
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
702-9
|
|
pubmed:dateRevised |
2010-10-29
|
|
pubmed:meshHeading |
pubmed-meshheading:19613840-AIDS-Related Opportunistic Infections,
pubmed-meshheading:19613840-Adult,
pubmed-meshheading:19613840-Antifungal Agents,
pubmed-meshheading:19613840-Cerebrospinal Fluid,
pubmed-meshheading:19613840-Cohort Studies,
pubmed-meshheading:19613840-Colony Count, Microbial,
pubmed-meshheading:19613840-Dose-Response Relationship, Drug,
pubmed-meshheading:19613840-Drug Therapy, Combination,
pubmed-meshheading:19613840-Female,
pubmed-meshheading:19613840-Fluconazole,
pubmed-meshheading:19613840-Humans,
pubmed-meshheading:19613840-Interferon-gamma,
pubmed-meshheading:19613840-Male,
pubmed-meshheading:19613840-Meningitis, Cryptococcal,
pubmed-meshheading:19613840-Prognosis,
pubmed-meshheading:19613840-Proportional Hazards Models,
pubmed-meshheading:19613840-Prospective Studies,
pubmed-meshheading:19613840-Randomized Controlled Trials as Topic,
pubmed-meshheading:19613840-South Africa,
pubmed-meshheading:19613840-Thailand,
pubmed-meshheading:19613840-Time Factors,
pubmed-meshheading:19613840-Treatment Outcome,
pubmed-meshheading:19613840-Uganda
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients.
|
|
pubmed:affiliation |
Centre for Infection, St. George's University of London, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
