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rdf:type |
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lifeskim:mentions |
umls-concept:C0007765,
umls-concept:C0011305,
umls-concept:C0034143,
umls-concept:C0040715,
umls-concept:C0221102,
umls-concept:C0332282,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0702216,
umls-concept:C1522702,
umls-concept:C2752551
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-17
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pubmed:abstractText |
Functional neural circuits are formed by eliminating early-formed redundant synapses and strengthening necessary connections during development. In newborn mouse cerebellum, each Purkinje cell (PC) is innervated by multiple climbing fibers (CFs) with similar strengths. Subsequently, a single CF is selectively strengthened by postnatal day 7 (P7). We find that this competition among multiple CFs occurs on the soma before CFs form synapses along dendrites. Notably, in most PCs, the single CF that has been functionally strengthened (the "winner" CF) undergoes translocation to dendrites while keeping its synapses on the soma. Synapses of the weaker CFs (the "loser" CFs) remain around the soma and form "pericellular nests" with synapses of the winner CFs. Then most perisomatic synapses are eliminated nonselectively by P15. Thus, our results suggest that the selective translocation of the winner CF to dendrites in each PC determines the single CF that survives subsequent synapse elimination and persistently innervates the PC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4-phosphonobutyric acid,
http://linkedlifedata.com/resource/pubmed/chemical/Aminobutyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Biotin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Protein, Vitamin...,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Slc17a6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Glutamate Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/biotinylated dextran amine,
http://linkedlifedata.com/resource/pubmed/chemical/calbindin,
http://linkedlifedata.com/resource/pubmed/chemical/enhanced green fluorescent protein,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 5 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-4199
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-18
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pubmed:meshHeading |
pubmed-meshheading:19607796-Age Factors,
pubmed-meshheading:19607796-Aminobutyric Acids,
pubmed-meshheading:19607796-Analysis of Variance,
pubmed-meshheading:19607796-Animals,
pubmed-meshheading:19607796-Animals, Newborn,
pubmed-meshheading:19607796-Biophysics,
pubmed-meshheading:19607796-Biotin,
pubmed-meshheading:19607796-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:19607796-Cerebellum,
pubmed-meshheading:19607796-Dendrites,
pubmed-meshheading:19607796-Dextrans,
pubmed-meshheading:19607796-Electric Stimulation,
pubmed-meshheading:19607796-Excitatory Postsynaptic Potentials,
pubmed-meshheading:19607796-Green Fluorescent Proteins,
pubmed-meshheading:19607796-Mice,
pubmed-meshheading:19607796-Mice, Inbred C57BL,
pubmed-meshheading:19607796-Mice, Transgenic,
pubmed-meshheading:19607796-Microscopy, Confocal,
pubmed-meshheading:19607796-Nerve Fibers,
pubmed-meshheading:19607796-Nerve Net,
pubmed-meshheading:19607796-Patch-Clamp Techniques,
pubmed-meshheading:19607796-Purkinje Cells,
pubmed-meshheading:19607796-Receptors, Serotonin,
pubmed-meshheading:19607796-Synapses,
pubmed-meshheading:19607796-Time Factors,
pubmed-meshheading:19607796-Vesicular Glutamate Transport Protein 2
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pubmed:year |
2009
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pubmed:articleTitle |
Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum.
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pubmed:affiliation |
Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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