Linked Life Data

1960431

Source:http://linkedlifedata.com/resource/pubmed/id/1960431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-1-9
pubmed:abstractText
A trace element selenium (Se) is an integral component of glutathione peroxidase (GSHPx) which is one of the important free radical scavenger. We previously reported that serum Se level and serum and myocardial GSHPx activities were significantly lower in infant rats than adult ones. Exactly the same conditions were made by feeding Se-deficient diet for 8 weeks in Wistar rats. Vulnerability to ischemic injury was tested using these Se-deficient rats. Wistar rats fed a commercial laboratory ration were used as a control. Isolated hearts were perfused aerobically with Krebs-Henseleit solution in the Langendorff mode for 15 minutes followed by coronary perfusion with St. Thomas Hospital cardioplegic solution. The hearts were subjected to 60 minutes global ischemia at 4 degrees C. The hearts were reperfused for 30 minutes in working mode, and aortic pressure, LV pressure, LV max dp/dt, coronary flow and aortic flow were measured. In Se-deficient rats aortic pressure (58.5 +/- 1.9 versus 77.3 +/- 8.5 mmHg, p less than 0.01), LV max dp/dt (2023 +/- 153 versus 2722 +/- 513 mmHg/sec, p less than 0.05), aortic flow (8.7 +/- 2.7 versus 17.0 +/- 2.5 ml/g wet wt., p less than 0.01), cardiac output (17.0 +/- 4.6 versus 24.6 +/- 2.0 ml/g wet wt., p less than 0.05) and stroke volume (67.5 +/- 11.6 versus 95.6 +/- 9.8 microliters/g wet wt., p less than 0.01) were significantly inferior to control rats. Then the hearts were iced instantly by fluid nitrogen and myocardial thiobarbituric acid reactive substance (TBARS) level was measured.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0369-4739
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1882-7
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Significance of selenium deficiency on myocardial protection of the mature and immature rat hearts].
pubmed:affiliation
Second Department of Surgery, Fukui Medical School, Japan.
pubmed:publicationType
Journal Article, In Vitro, English Abstract