Source:http://linkedlifedata.com/resource/pubmed/id/19603545
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2009-7-14
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pubmed:abstractText |
The dopamine D2 receptor (DRD2) plays an important role in the reinforcing and motivating effects of ethanol. Several polymorphisms have been reported to affect receptor expression. The amount of DRD2, expressed in a given individual, is the result of the expression of both alleles, each representing a distinct haplotype. We examined the hypothesis that haplotypes composed of polymorphisms, associated with reduced receptor expression, are more frequent in alcoholics compared with healthy individuals.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1744-6872
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-27
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pubmed:meshHeading |
pubmed-meshheading:19603545-Adult,
pubmed-meshheading:19603545-Alcohol Drinking,
pubmed-meshheading:19603545-Alcoholism,
pubmed-meshheading:19603545-Case-Control Studies,
pubmed-meshheading:19603545-Family,
pubmed-meshheading:19603545-Female,
pubmed-meshheading:19603545-Genetic Predisposition to Disease,
pubmed-meshheading:19603545-Haplotypes,
pubmed-meshheading:19603545-Humans,
pubmed-meshheading:19603545-Linkage Disequilibrium,
pubmed-meshheading:19603545-Male,
pubmed-meshheading:19603545-Polymorphism, Single Nucleotide,
pubmed-meshheading:19603545-Receptors, Dopamine D2
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pubmed:year |
2009
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pubmed:articleTitle |
Association of the dopamine D2 receptor gene with alcohol dependence: haplotypes and subgroups of alcoholics as key factors for understanding receptor function.
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pubmed:affiliation |
Charité - Universitätsmedizin Berlin, Klinik für Psychiatrie and Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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