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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-5-14
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pubmed:abstractText |
Oral epithelial cells help to prevent against bacterial infection in the oral cavity by producing antimicrobial peptides (AMPs). A broad-spectrum AMP, calprotectin (a complex of S100A8 and S100A9 proteins), is expressed by oral epithelial cells and is up-regulated by interleukin-1alpha (IL-1alpha). Shosaikoto (SST) is a traditional Japanese herbal medicine that has immunomodulatory effects and is reported to enhance the levels of IL-1alpha in epithelial cells. The purpose of this study was to investigate the effect of SST on the expression of calprotectin and other AMPs through the regulation of IL-1alpha in oral epithelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Calgranulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Calgranulin B,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Leukocyte L1 Antigen Complex,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1 Type I,
http://linkedlifedata.com/resource/pubmed/chemical/shosaiko-to
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1600-0765
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-86
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pubmed:meshHeading |
pubmed-meshheading:19602113-Antimicrobial Cationic Peptides,
pubmed-meshheading:19602113-Blotting, Northern,
pubmed-meshheading:19602113-Calgranulin A,
pubmed-meshheading:19602113-Calgranulin B,
pubmed-meshheading:19602113-Cell Line, Tumor,
pubmed-meshheading:19602113-Cells, Cultured,
pubmed-meshheading:19602113-Drugs, Chinese Herbal,
pubmed-meshheading:19602113-Epithelial Cells,
pubmed-meshheading:19602113-Humans,
pubmed-meshheading:19602113-Immunologic Factors,
pubmed-meshheading:19602113-Interleukin-1alpha,
pubmed-meshheading:19602113-Leukocyte L1 Antigen Complex,
pubmed-meshheading:19602113-Mouth Mucosa,
pubmed-meshheading:19602113-Polymerase Chain Reaction,
pubmed-meshheading:19602113-RNA, Messenger,
pubmed-meshheading:19602113-Receptors, Interleukin-1 Type I,
pubmed-meshheading:19602113-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19602113-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Shosaikoto increases calprotectin expression in human oral epithelial cells.
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pubmed:affiliation |
Department of Periodontology and Endodontology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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