Linked Life Data

19591275

Source:http://linkedlifedata.com/resource/pubmed/id/19591275

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-7-13
pubmed:abstractText
We reviewed correlations among telomere length, aging and carcinogenesis. Southern blot analysis showed that telomere shortening occurred with aging in all human tissues except for brain and myocardium. We investigated the telomere lengths of individual cell types in human tissues using a Q-FISH method and an original software package, "Tissue Telo". Q-FISH revealed that in squamous epithelia, NTCR corresponding to telomere length was significantly highest in basal cells and lowest in prickle cells, and that telomere length regressed at a certain rate in each cell type except for fibroblasts. Mean telomere length was significantly less in background tissue squamous epithelia of patients with cancer than in normal controls without cancer. We demonstrated telomere shortening and chromosomal instability in the background and normal control with excessively shortened telomeres. The data suggest that cancer arises from epithelial cells with short telomeres.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1293-7
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Telomere].
pubmed:affiliation
Research Team for Aging-related Diseases, Tokyo Metropolitan Institute of Gerontology.
pubmed:publicationType
Journal Article, English Abstract, Review