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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-1-3
|
| pubmed:abstractText |
6,6'Di-O-mycoloyl-beta,beta-trehalose (beta,beta-TDM) and 6,6'-di-O-mycoloyl-alpha,beta-trehalose (alpha,beta-TDM) were synthesized and their toxicity and ability to activate peritoneal macrophages in situ were examined in mice, in comparison with 6,6'-di-O-mycoloyl-alpha,alpha-trehalose (TDM). Both beta,beta-TDM and alpha,beta-TDM caused a decrease in body weight two days after injection, however the weights reverted to a normal level. No deaths were caused by either analog. On the other hand, TDM showed potent toxicity, causing decrease in body weight and death of all animals injected. Beta,beta-TDM and alpha,beta-TDM were effective in the in situ activation of mouse peritoneal macrophages.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0008-6215
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
212
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
47-53
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1959122-Animals,
pubmed-meshheading:1959122-Body Weight,
pubmed-meshheading:1959122-Carbohydrate Sequence,
pubmed-meshheading:1959122-Cord Factors,
pubmed-meshheading:1959122-Macrophages,
pubmed-meshheading:1959122-Mice,
pubmed-meshheading:1959122-Molecular Sequence Data,
pubmed-meshheading:1959122-Peritoneal Cavity,
pubmed-meshheading:1959122-Structure-Activity Relationship
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Chemical synthesis and biological activities of 6,6'-di-O-mycoloyl-beta,beta- and -alpha,beta-trehalose.
|
| pubmed:affiliation |
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
|
| pubmed:publicationType |
Journal Article
|