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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-10-5
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pubmed:abstractText |
Bcl-2 is a major regulator of neural plasticity and cellular resilience. A single nucleotide polymorphism (SNP) in the Bcl-2 gene, Bcl-2 rs956572, significantly modulates the expression of Bcl-2 protein and cellular vulnerability to apoptosis. We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-10913502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-11525331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-12451107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-16226876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-16566899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-16612219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-16960143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-17400299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-18704495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-18707678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-19008895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-2094891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-9202314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589501-9930766
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
804-7
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19589501-Adult,
pubmed-meshheading:19589501-Alleles,
pubmed-meshheading:19589501-Basal Ganglia,
pubmed-meshheading:19589501-Brain,
pubmed-meshheading:19589501-Brain Mapping,
pubmed-meshheading:19589501-Female,
pubmed-meshheading:19589501-Genes, bcl-2,
pubmed-meshheading:19589501-Genotype,
pubmed-meshheading:19589501-Humans,
pubmed-meshheading:19589501-Magnetic Resonance Imaging,
pubmed-meshheading:19589501-Male,
pubmed-meshheading:19589501-Middle Aged,
pubmed-meshheading:19589501-Neural Pathways,
pubmed-meshheading:19589501-Organ Size,
pubmed-meshheading:19589501-Polymorphism, Single Nucleotide
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pubmed:year |
2009
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pubmed:articleTitle |
Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans.
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pubmed:affiliation |
Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. salvadoreg@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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